drhowarddrfine - 3:43 pm on Nov 23, 2012 (gmt 0)
It's definitely more work but the payoff is great. At times I felt a bit overwhelmed and thought we didn't have the time or personnel to handle all that but, the more you do, the more Aha! moments you have which makes the work easier, or at least more comprehensible.
The first thing you need to get rid of is the thought of "all those screen resolutions" and concentrate on design by content.