tedster - 5:08 pm on May 16, 2011 (gmt 0)

With regard to search engines, using tables for layout can run into this type of problem:

The content in two table cells may be related to each other IN MEANING when the page is rendered visually...

But in the source code, those two bits of content may be widely separated by all kinds of table mark-up and other table cells. Because of this, the intended semantic connection is lost to machine intelligence that is trying to score the page.