piatkow - 6:14 am on May 21, 2010 (gmt 0)
I would take the route of first deciding what might earn revenue based on the topic of the site. Then look for networks with appropriate affiliates on their books.
I have tried some lateral thinking in the past about what to put on a site but the things that I thought would get some crossover sales didn't. Experiment with your page estate and see what works for you.