lorax - 1:01 am on Jul 8, 2013 (gmt 0)
Largely do it once and forget about it. The only issue is that unless you have a dedicated IP connection to the INet, your IP addy will change at some point. Then all you need to do is to update the IP addy in the htaccess files to the new IP and you're good to go.
FYI - I modify the htaccess file in the web root to lock down wp-login.php and another htaccess file in the wp-admin directory to lock that directory down. The block only affects http calls and not FTP so you can still edit and upload files.