rogerd - 10:01 pm on May 19, 2011 (gmt 0)
There are a bunch of online tools to check what all a page is loading, and tools like Fiddler, Yslow, etc. that run locally. They should very quickly highlight what's slowing the page down. Then, you can determine the best strategy - cache, CDN, or removal of the problematic content. I've seen external ad tags kill page loads, tracking scripts too. Iframing the problematic stuff can at least ensure that a problem at the ad server won't result in blank pages on your site.
If you are running plugins, disabling them all and turning them back on one at a time might be worth a try, too.