Guru I sympathize with you in general but I'm not sure there's any call for a change in layout mindset. From notepad to newspaper? No.
Rather, with CSS you can set higher resolution fonts etc. I would stop there.
1) While PC screens are rapidly becoming 1280px wide at least (and to hell with any idiot still using a 1024 screen hahah), you are ignoring the rapidly growing market which is simply following the same path as laptops 20 years ago: mobile devices, including pads, which now have respectable enough resolutions not to need to rely on 50% zooms or reprocessing solutions like Opera Mobile. Aren't you looking forward to seeing that sizable section of 800x600 viewers again? LOL
2) As above lots of users with large screens do not maximize their browser windows. I have a 24" which is 1920px, very common now, maximized is too big on most sites. The likes of Wikipedia are the worst culprits, full spread divs with no max-width at all. Ugh. Try 27" or 30" screens - forget it, even folk like Ken above with a 1280px laptop are creating 'problems' for you.
I try to keep content very linear with a clear structure that any device can make sense of, and use clear CSS to hint styling - large fonts and div widths for PCs, smaller fonts for mobiles, print layout for print, etc.