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AlexK - 2:25 am on Dec 20, 2006 (gmt 0)
All the humans doing spam-postings were using either web.de or mail.ru as their email address. Once each was banned on a wild-card, *all* spam postings stopped dead, instantly. The forums on my site operate at a fairly low level, so my experience may not match others' experience.
Requiring Registration + Activation, then setting a custom parameter at Registration has stopped all bot signups + postings from initiation. It did leave the forum with a low-level of human spam-postings, however, until a recent discovery.