About 5 years ago, I spent 2 months playing with TK. It took forever to come to terms with many of the widgets and how the perl mods fit together with it.
Last night, I ran onto WXGlade [wxglade.sourceforge.net] GUI WX widget framework builder. When done designing your frame/interface, you press "generate code" and it creates the perl code for you (or python, lisp, or C++).
In under 5 minutes I had created a basic program framework and interface. I was pretty amazed when I pressed run on the generated code an my new program popped up. It looked and felt native windows.
I highly recommend that if you are looking for a GUI builder for perl to give WX and WXPerl a try.
You must run Perl v 5.8.8 to install the latest binary of WxPerl. After that is up and running - then dl and run WXGlade.