I did not think it was possible with PPC, but after two years of advertising with google adwords my ROI has turned negative. This is due to google stupid mininum bids on keywords that helped my ROI in the past, now at a ridiculous, insane amount.
What Google seems to forget is that MSN and Yahoo are in the game. I am also tired of google reps not caring about my ROI but how much money google can take from me without regard with how my business is doing. What Google does not get is if I don't win, google does not win.