EPC is sensless without CTR. Every program can have complete different CTR depending on the ad targeting.
This can easy influence CTR in a range of 1:100 from great targeting to complete anti targeting.
So even when gambling affliant paradies would pay $10 per click, and the visitors of my page do not like gambling - anti targeting - $0,20 from AdSense could bring much more because CTR is maybe 100 times better.
In the year 2000, I stoped banner advertising on my sites, because the ads had been completely anti targeted to the users of my site and the CTR had been a joke.