The tips I'd suggest might seem common sense to some people but maybe not to others.
1. 1000 impressions seems like a lot, but in a popular category it will go in no time at all. I'd suggest you start your campaign off using exact match for your keywords [square brackets]. If you don't get a good number of impressions and clicks then try phrase match "inverted commas" and if that doesn't work then try it with all the safeties off.
2. Use some form of tracking facility to allow you to understand the search parameters for those that do click on your ad. In some industries what you want is not what you get, and you may be lulled into thinking your campaign is working when it isn't.
3. Google prefer continuity of your ads. Although you can pause the ads, it is better to leave it running, the click popularity is important to your price and also your importance, if you pause the ad sometimes you can lose your space at the table.
4. Put the expensive keywords in a campaign all on their own, don't leave them in a pool with all your less expensive ads as they will drag the overall cost of your ads up. This happens because invariably the higher competition keywords have a lower CTR as more people are vying for market share.
5. Syndicated partners can be your friends but can also kill you. If you find that you are struggling with keeping ads alive then switch off syndication for a while.
6. Don't load up your ad groups with lots of keywords. Small keyword groups work far better for me. This also generally makes the ads a tighter fit with the keywords in question.
7. Try 3 or 4 different headlines with 3 or 4 ads and the same keywords to see which ones work over a period. Once you have established the best ones eliminate all the non-performing ads, no point rotating them with the ones that do work as it's wasted impressions.
8. Certainly in the UK don't take the estimates that are shown as gospel. In some instances the numbers will be woefully inaccurate (I hope eventually Google will have a UK specific database to help advertisers). Try things for a little while and if a keyword doesn't hit, then delete it or try it in another group with a different ad.
9. Don't assume that the same keywords that work on Google will work on other PPC's. Each has it's own idiosyncracies.
10. Be prepared to invest some capital in Adwords, almost as R & D. It's quick to get results from and those results will transfer across to normal SERPs too.
There's more, but don't want to give all our secrets away!