I almost always boost the saturation before saving an image. That one stpe gives a lot of extra pop on screen, especially if an image has been through any CMYK color space. And I do use ImageReady because the compression is much better.
The thing is, with the varying graphics cards, monitors, color depths, O/S and browsers that are in use (and who knows what other variables, like AOL's compression!) the web is just not the place for getting too particular about precise color.