1) With our commerce sites sales plummet for a few days around and especially on every holiday. Christmas is the worst... 70% traffic and sales drop. Thanksgiving and New Years are bad. I'm pretty sure this effect applies to nearly all online shopping.
2) All orders from "certain" African countries are fraudulent.
Rural areas are pretty much tailor-made for Internet businesses, as far as I am concerned.
I think that is true for most mail order businesses, and for more than just a rent issue. If you have employees, chances are a rural area will be much better. YOur employees will be more loyal (less options for jobs) and will cost less (their rent and COL is less too so they will take less in pay).
I know of a rather large catalog company that hand selects a new small town everytime they want to open a new warehouse. They try to find towns that are very rural and have high unemployment. The warehouse will bring a few hundred jobs to the town, people have few options as to where else to work and the town many times gives them concessions on taxes and ordinances. It may seem a bit unfair, but nobody feels taken advantage of. The towns people are able to stay in the town they grew up in plus there is new taxes coming in (even with tax breaks you get an influx of personal income tax) and the business saves money.