Middle of the night the system kicked on and the monitors were totally whacked. Having recently replaced the video card after the old one smoked my first reaction was to fear the worst that I was losing yet another video card.
I have a dual 24" screen setup with screen #1 in portrait mode and #2 in landscape but it appears that somehow the monitors switched which was #1 and #2 which led to both appearing to be sideways and getting the mouse where it needed to be to fix it was frustrating at best.
Turns out NVIDIA had a driver update last night and it went to hell.
The monitors swapped locations which was a total pain and when I straightened that out it was going wacky in the monitor setup pages like showing both as #1 or other odd things and certain fancy Windows features such as window previews over the task bar and the glass effects on the windows borders didn't work, etc. Another fun artifact was when the power mode shut off the screens when I woke up the PC the #2 screen didn't power up unless you logged out and logged in again, real PITA issues. Then the video driver started crashing, rebooting itself multiple times, finally blue screen reboot happened.
I quickly located the advanced screen settings page and did a driver rollback and VOILA! everything was back to normal.
I don't know what NVIDIA did in the new release, but I'm sure as heck not going to reinstall it and see what happens.
The only gotcha is my NVIDIA card sees monitor #1 as the Gateway monitor properly but Windows still thinks it's a Generic PnP monitor yet it knows #2 is a ViewSonic. Not like that's such a big deal but I couldn't get it to update the Windows profile properly and short of uninstalling and reinstalling I don't think there's any other way to resolve this.
Not like it's a big deal since everything seems to be working and I'm not really in the mood to risk watching everything go to hell all over again doing a reinstall.