I love Portland!
Beautiful city, but high housing costs. Kid friendly, clean, fresh, great restaurants, a ton of things to do outdoors (if you can stand the rain), easy to get to the mountains, the coast, etc.
Definitely one of the best "big cities" I've been to, but I suppose that depends on what you're looking for. I'm from the Northwest, so I may be somewhat biased. :-)
I live in Southern Oregon, have been to P-town quite a few times.
The museums and galleries are great, there are lots of small and large galleries.
The rose gardens and OMSI are must-see's.
As cities go, I grew up in L.A., and Portland is pretty well managed, there is still a lot of "country" about, but it's still a city. If you're into grass roots music, you'll find lots of places to rock. :-)
I love Portland. Great city, friendly people lots of micro-brewers etc. Good music scene. It used to be a bit of a tech city, not so sure about that now.
The place is full of tech-geeks and Deadheads all clutching an industrial strength coffee. Stand on any downtown corner and you will find that is true.
I will be there in just a couple of weeks again.
One of the American cities I would seriously consider moving too.
I've been through Portland once, and left with a good impression. I was stuck there, short on cash for a ticket out. In 4 hours I was on my way.. kind people.