What is the best software choice for running multiple blogs / domains from one installation (like Wordpress, TypePad, MovableType etc). Not exactly the same blog with multiple domains, but different blog / content / layout, for every domain, but from one CMS installation.
Wordpress works for multiple blogs, but it's a bit complicated for multiple domains [codex.wordpress.org...]
Drupal is the easiest I've used. Multiple domain support (called multisite) is built in and it's dead easy. You'll want to keep the number of modules to a minimum and standardized across all blogs, though, otherwise maintenance can get to be a headache (module needs updating for one blog, but the update is incompatible with a module that another blog needs = bad)