Msg#: 3873621 posted 11:11 pm on Mar 18, 2009 (gmt 0)
What kind of spam? Comment bots, or what is happening?
You could ban IPs, but it's likely distributed.
You could look for a bad bot plugin for WP (oe must exist).
You coudl install something like Captcha or WP Hashcash if the problem is the flood of spam comments (how many per day are you talking about?). Akismet only works after submission, so it doesn't stop comments from getting submitted and all the DB load that causes.